The State Key Laboratory for Manufacturing Systems Engineering is based on Xi’an Jiaotong University. The key lab was formed in 1988, and composed of three key disciplines including: Mechanical manufacturing and automation; system engineering and management engineering. The current director of the Key lab is Prof. Li Dichen, and the director of the Academic Committee is Academician Tan Jianrong.

The Lab now has 79 permanent staff, including four Chinese Academicians of Engineering. In the frontier research, the lab mainly focuses on the additive manufacturing, micro/nano manufacturing, bio-manufacturing in the multi-discipline mode. In engineering applications, the lab focuses on the development of the high-speed processing, high-precision measurement, assembly technology. and through the advocacy and implementation of the "service-oriented manufacturing", the Lab aims to navigate the manufacturing sector from traditional production manner to the service-oriented manner.

The laboratory has a centralized area of about 30,000 square meters and 70 sets of equipment. The Lab is managed via the implementation of "open, dynamic, competition and joint", aiming to stimulatethe science and technology innovation and service/support capability and quality.